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Fibromyalgia is considered a neurological disorder that affects the way the brain processes pain signals, leading to a heightened perception of pain. It's characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive issues.
Though its exact cause is not fully understood, it is believed to result from a combination of genetic, environmental, and psychological factors. Some common triggers or risk factors include physical trauma, infections, stress, and certain genetic factors.
Fibromyalgia affects millions of people worldwide, but diagnosing it can be challenging, as there is no specific test for it. Healthcare providers rely on a thorough medical history, physical examination to identify tender points, and the exclusion of other potential causes of the symptoms to make a diagnosis.
Gout is a form of inflammatory arthritis caused by the accumulation of uric acid crystals in the joints. It commonly affects the big toe but can also target other joints in the body.
Uric acid is a natural waste product formed when the body breaks down purines, which are found in certain foods and beverages. In individuals with gout, the body produces excessive amounts of uric acid or fails to eliminate it adequately, leading to its deposition in the joints.
The hallmark symptom of gout is sudden and severe joint pain. The affected joint can become swollen, red, and tender to the touch. Gout attacks often occur at night and can last for several days or weeks at a time. Between flare-ups, the joints may appear just fine.
While gout and fibromyalgia appear to be distinct conditions, recent studies have hinted at a possible association between the two.
Some researchers have hypothesized that the uric acid crystals found in gout may trigger an immune response and inflammatory cascade, which could potentially worsen fibromyalgia symptoms.
Consequently, by treating and reducing uric acid levels in gout patients, fibromyalgia symptoms may also be alleviated.
According to Fibromyalgia News Today, after only one month’s treatment with a medicine named Allopurinol (used for gout and high levels of uric acid), the pain was significantly lessened for women with fibromyalgia who did not respond to conventional therapies.
Gout treatment primarily focuses on reducing uric acid levels and preventing crystal formation. Medications commonly used for gout management include nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, corticosteroids, and urate-lowering therapy (ULT) agents such as allopurinol and febuxostat.
ScienceDirect has a pilot study that shows the effects that allopurinol has on pain and anxiety in fibromyalgia patients. The main potent inhibitor of the medicine is an enzyme called xanthine oxidase which is what is used for gout treatment.
Urate-lowering therapy (ULT) agents, like allopurinol and febuxostat, are used to decrease uric acid levels in gout patients. These drugs have been found to possess anti-inflammatory properties beyond their uric acid-lowering effects.
Some studies have suggested that the reduction in systemic inflammation achieved through ULT agents may also lead to an improvement in fibromyalgia symptoms.
While the potential link between gout treatment and fibromyalgia pain relief is intriguing, it is important to note that more research is needed to establish a definitive connection and determine the most effective treatment strategies.
Fibromyalgia is a complex condition with multiple factors contributing to its onset and progression. Therefore, a comprehensive and individualized approach to fibromyalgia management, which may include a combination of pharmacological and non-pharmacological interventions, remains the standard of care.
Sources:
Fibromyalgia News Today - Gout Treatment Found to 'Significantly' Lessen Fibromyalgia Pain
ScienceDirect - Effects of allopurinol on pain and anxiety in fibromyalgia patients: a pilot study
