Recent Advances in Understanding and Managing Gout

Hyperuricemia Clinical Trial

Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout and its associated conditions on patient morbidity and mortality. Unfortunately, gout remains under-diagnosed and under-treated in the general community. Despite major advances in treatment strategies, as many as 90% of patients with gout are poorly controlled or improperly managed and their hyperuricemia and recurrent flares continue. The introduction of novel urate-lowering therapies, new imaging modalities, and a deeper understanding of the pathogenesis of gout raise the possibility of better gout care and improved patient outcomes. Here, we spotlight recent advances in the diagnosis and management of gout and discuss novel therapeutics in gout treatment.

Science and Clinical Data by U.S. National Center for Biotechnology Information

The Effectiveness of Melatonin for Promoting Healthy Sleep: A Rapid Evidence Assessment of the Literature

Melatonin Effectiveness


A systematic review was conducted using Samueli Institute’s Rapid Evidence Assessment of the Literature (REAL©) process to determine the evidence base for melatonin as an agent to optimize sleep or improve sleep quality, and generalize the results to a military, civilian, or other healthy, active, adult population. Multiple databases were searched yielding 35 randomized controlled trials (RCTs) meeting the review’s inclusion criteria, which were assessed for methodological quality as well as for melatonin effectiveness. The majority of included studies were high quality (83.0%). Overall, according to Grading Recommendations, Assessment Development and Evaluation (GRADE) methodology, weak recommendations were made for preventing phase shifts from jet lag, for improving insomnia in both healthy volunteers and individuals with a history of insomnia, and for initiating sleep and/or improving sleep efficacy. Based on the literature to date, no recommendations for use in shift workers or to improve hormonal phase shift changes in healthy people can be made at this time. Larger and longer-duration RCTs utilizing well characterized products are needed to warrant melatonin recommendations in young, healthy adults.

Science and Clinical Data by U.S. National Center for Biotechnology Information

Bio-availability of Liquid Extracts vs. Capsules / Tablets

Liquid Dropper

Why Take Liquid Extracts Over Capsules or Tablets?

Medical studies have shown that liquid extracts have faster absorption rates; higher optimization rates and is more easily digestible. Liquids may have a big advantage over pills when it comes to swallowing. Most people, especially the elderly and young children, tend to have more difficulty swallowing some pills. Generally, supplements in liquid form are much more readily broken down and absorbed. Additionally, it has been shown that liquids are more completely and quickly absorbed than most capsules and pills.

Science and Clinical Data by Medicare Europe


Real Health Interview with Vincent Tones about Lifetones Uric Acid Support

Vincent Tones: "There's three different types of acids in the body...three main forms. First, there's hydrochloric acid which is a good acid. It helps with digestion; to improve it.

Second is lactic acid; it's found in runners, people exercising, breathing a lot. In other words, they aren't getting their carbon dioxide out of the lungs, and that converts ultimately into a form of acid in the muscles which causes cramping, slow recovery time and muscles spasms.

Uric acid is the big problem child. It's due to our diets, our lifestyles, stress, medications, and predominantly man-made foods.Those all convert into a high-acidity type environment in the blood and works its way into the extremities. This is the one that causes crystals in the joints; it causes pain, arthritis, gout, fibromyalgia. So uric acid is probably the cause of almost every ailment, or amplifies the ailment and makes it worse."